From reaction networks to information flow--using modular response analysis to track information in signaling networks.

@article{Schulthess2011FromRN,
  title={From reaction networks to information flow--using modular response analysis to track information in signaling networks.},
  author={Pascal Schulthess and Nils Bl{\"u}thgen},
  journal={Methods in enzymology},
  year={2011},
  volume={500},
  pages={
          397-409
        }
}
Even if the biochemical details of signaling networks are known, it is often hard to track how information flows through the network. In combination with experimental techniques, modular response analysis has proven useful in analyzing the quantitative information transfer in signal transduction networks. The sensitivity of a target (e.g., transcription factor, protein) to an upstream stimulus (e.g., growth factor) can be determined by a so-called response coefficient. We have used this… CONTINUE READING

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