From rationally designed polymeric and peptidic systems to sophisticated gene delivery nano-vectors.

@article{Parhiz2013FromRD,
  title={From rationally designed polymeric and peptidic systems to sophisticated gene delivery nano-vectors.},
  author={Hamideh Parhiz and Wayne Thomas Shier and Mohammad Bagher Ramezani},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={457 1},
  pages={237-59}
}
Lack of safe, efficient and controllable methods for delivering therapeutic genes appears to be the most important factor preventing human gene therapy. Safety issues encountered with viral vectors have prompted substantial attention to in vivo investigations with non-viral vectors throughout the past decade. However, developing non-viral vectors with effectiveness comparable to viral ones has been a challenge. The strategy of designing multifunctional synthetic carriers targeting several… CONTINUE READING
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