From patient to tube: the importance of physiologically relevant quantitative bioanalytical assays.

@article{Summerfield2016FromPT,
  title={From patient to tube: the importance of physiologically relevant quantitative bioanalytical assays.},
  author={Scott G. Summerfield and Matthew Barfield and Neil Spooner and Steve White},
  journal={Bioanalysis},
  year={2016},
  volume={8 24},
  pages={2595-2604}
}
Circulating drug concentrations (clinical or preclinical) underly many interactions between industry and regulators; expressing safety coverage, pharmacokinetic-pharmacodynamic relationships or defining bioequivalence and dosing regimens. Accurate and precise measurement of these circulating concentrations is pivotal to the evolution and validation of any bioanalytical method that supports regulatory interactions. Since the bioanalyst is presented with a sub-aliquot of sampled biological matrix… CONTINUE READING