From pathomechanisms to prediction, prevention and improved care of insulin-dependent diabetes mellitus in children.

@article{Akerblom1997FromPT,
  title={From pathomechanisms to prediction, prevention and improved care of insulin-dependent diabetes mellitus in children.},
  author={Hans K. Akerblom and Mikael Knip and Olli Simell},
  journal={Annals of medicine},
  year={1997},
  volume={29 5},
  pages={383-5}
}
Molecular biology, gene technology and immunology have extensively clarified the aetiology and pathogenesis of insulin-dependent diabetes mellitus (IDDM). It is now obvious that the genetic background of the individual, poorly characterized environmental factors and aggressive autoimmune phenomena in a complex interplay contribute to the progression to clinical IDDM. The IDDM risk associated with certain genetic markers, e.g. the risk alleles at various HLA loci, the most strongly predisposing… CONTINUE READING