From pathogenesis to treatment of chronic lymphocytic leukaemia

  title={From pathogenesis to treatment of chronic lymphocytic leukaemia},
  author={Thorsten Zenz and Daniel Mertens and Ralf K{\"u}ppers and Hartmut D{\"o}hner and Stephan Stilgenbauer},
  journal={Nature Reviews Cancer},
Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and there is only a small proliferative compartment; however, the progressive accumulation of malignant cells will ultimately lead to symptomatic disease. Pathogenic mechanisms have been elucidated that involve multiple external (for example, microenvironmental stimuli and antigenic drive) and internal (genetic and… CONTINUE READING
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