From pathogenesis to hormone prevention of mammary carcinogenesis.

  title={From pathogenesis to hormone prevention of mammary carcinogenesis.},
  author={I H Russo and Jos{\'e} Russo},
  journal={Cancer surveys},
  volume={5 3},
The study of an experimental model, the induction of breast carcinomas by administration of the chemical carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) to virgin rats, has allowed us to determine that the susceptibility of the mammary gland to a carcinogen depends upon its degree of differentiation at the time of exposure. The mostly undifferentiated gland of young virgin rats is highly susceptible due to the high proliferative rate of the terminal ductal structures or terminal end buds (TEBs… CONTINUE READING


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