Cardiologists’ Perspectives on BiDil and the Use of Race in Drug Prescribing
- MedicineJournal of Racial and Ethnic Health Disparities
Cardiologists’ attitudes and prescribing patterns specific to the use of generic isosorbide dinitrate and hydralazine hydrochloride, and the fixed-dose patented drug, BiDil, provide useful findings that, when viewed within the context of ongoing debates about race-based medicine, show little progress toward appropriately utilizing BiDIL to maximize health outcomes.
Qatar genome: Insights on genomics from the Middle East
- BiologyHuman mutation
It is found that several rare deleterious variants were more common in the Qatari population while others seem to provide protection against diseases and have shaped the genetic architecture of adaptive phenotypes.
Envisioning the next human genome reference
- BiologyDisease models & mechanisms
Summary: We provide an Editorial perspective on approaches to improve ethnic representation in the human genome reference sequence, enabling its widespread use in genomic studies and precision…
ShaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores
We present shaPRS, a novel method that leverages widespread pleiotropy between traits, or shared genetic effects across ancestries, to improve the accuracy of polygenic scores. The method uses…
Open science, data sharing and solidarity: who benefits?
- Computer ScienceHistory and philosophy of the life sciences
This paper reports on the outcomes of discussions by the panel “Open science, data sharing and solidarity: who benefits?” held at the 2021 Biennial conference of the International Society for the History, Philosophy, and Social Studies of Biology.
Qatar Genome: Insights on Genomics from the Middle East
Insight into the genetic structure of the Qatari population revealed five non-admixed subgroups and the heritability and genetic marker associations for 45 clinical traits highlight the value of data as a resource to advance genetic studies in the Arab and neighbouring Middle Eastern populations.
Global Mapping of Indigenous Resilience Facing the Challenge of the COVID-19 Pandemic
- Political Science
Indigenous social development scenarios must be understood as the possibility of improving the sustainability of the planet and human health in the face of the COVID-19 pandemic. Integrating the…
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High-depth African genomes inform human migration and health
The findings refine the current understanding of continental migration, identify gene flow and the response to human disease as strong drivers of genome-level population variation, and underscore the scientific imperative for a broader characterization of the genomic diversity of African individuals to understand human ancestry and improve health.
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
- BiologyNature Communications
A genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group, is reported and a locus, ZRANB3, is identified that is specific for this population is identified.
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
This high-density SNP map provides a public resource for defining haplotype variation across the genome, and should help to identify biomedically important genes for diagnosis and therapy.
Clinical use of current polygenic risk scores may exacerbate health disparities
- Medicine, BiologyNature Genetics
To realize the full and equitable potential of polygenic risk scores, greater diversity must be prioritized in genetic studies, and summary statistics must be publically disseminated to ensure that health disparities are not increased for those individuals already most underserved.
The Sequence of the Human Genome
The genomic landscape of African populations in health and disease
- BiologyHuman molecular genetics
A deeper appreciation of the complex architecture of African genomes is critical to the global effort to understand human history, biology and differential distribution of disease by geography and…
Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans
In African Americans, focal segmental glomerulosclerosis and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22, which speculate that evolution of a critical survival factor in Africa may have contributed to the high rates of renal disease in African Americans.
Initial sequencing and analysis of the human genome.
The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Human ancestry correlates with language and reveals that race is not an objective genomic classifier
- BiologyScientific Reports
Ancestry data yield insight into a deeper past than linguistic data can, while linguistic data provide clarity to ancestry data, and indicate that continents, ethno-linguistic groups, races, ethnicities, and individuals all show substantial ancestral heterogeneity.