From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation.

@article{Gurdon2006FromNT,
  title={From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation.},
  author={J. B. Gurdon},
  journal={Annual review of cell and developmental biology},
  year={2006},
  volume={22},
  pages={
          1-22
        }
}
  • J. Gurdon
  • Published 9 October 2006
  • Biology
  • Annual review of cell and developmental biology
This is a personal historical account of events leading from the earliest success in vertebrate nuclear transfer to the current hope that nuclear reprogramming may facilitate cell replacement therapy. Early morphological evidence in Amphibia for the toti- or multipotentiality of some nuclei from differentiated cells first established the principle of the conservation of the genome during cell differentiation. Molecular markers show that many somatic cell nuclei are reprogrammed to an embryonic… 

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