From nonuniform repolarization to abnormal calcium dynamics: the elusive culprit for ventricular arrhythmias in heart failure.

Abstract

d t F f s Patients with systolic dysfunction have an elevated risk or sudden cardiac arrest (SCA) from ventricular arrhythias (VT/VF), although for unclear reasons. An improved nderstanding of the mechanisms linking structural disease ith VT/VF is clearly needed to better identify and manage ndividuals at high arrhythmic risk. Notably, arrhythmic risk elated to systolic dysfunction is substantial whether paients are selected because of reduced ejection fraction, ymptomatic heart failure, presence or absence of coronary isease, conducting system disease, inducible arrhythmias n programmed ventricular stimulation, or other factors. hus, although arrhythmias may result from a wide pathohysiologic spectrum including scar, neuronal, hormonal, nd metabolic sequelae of heart failure, the presence of ystolic dysfunction itself may be an important substrate.

DOI: 10.1016/j.hrthm.2008.11.025

Cite this paper

@article{Narayan2009FromNR, title={From nonuniform repolarization to abnormal calcium dynamics: the elusive culprit for ventricular arrhythmias in heart failure.}, author={Sanjiv M. Narayan}, journal={Heart rhythm}, year={2009}, volume={6 2}, pages={260-2} }