From natural products to clinically useful antifungals.

@article{Barrett2002FromNP,
  title={From natural products to clinically useful antifungals.},
  author={David Barrett},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1587 2-3},
  pages={224-33}
}
In our search for natural products with a broad spectrum of antifungal activity as lead compounds for novel treatments for mycoses, we have isolated echinocandin-type lipopeptide FR901379 and lipopeptidolactone FR901469, as novel water-soluble antifungal agents that inhibit the synthesis of 1,3-beta-glucan, a key component of the fungal cell wall. Since the cell wall is a feature unique to fungi and is not present in nonfungal eukaryotic cells, inhibitors of the synthesis of fungal cell wall… CONTINUE READING
33 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Caspofungin

  • B. M. Lomaestro
  • an echinocandin antifungal for the treatment of…
  • 2002
1 Excerpt

An expedient synthesis of the amide analog of the potent antifungal lipopeptidolactone FR901469

  • D. Barrett, A. Tanaka, A. Fujie, N. Shigematsu, M. Hashimoto, S. Hashimoto
  • Tetrahedron Lett. 42
  • 2001
1 Excerpt

Current status of h-1,3-glucan synthase inhibitors from microbial products as systemic antifungal agents

  • Y. Hori
  • Kagaku to Seibutsu
  • 2001
1 Excerpt

Fr131535

  • A. Fujie, T. Iwamoto, +6 authors S. Hashimoto
  • a novel water-soluble D. Barrett / Biochimica et…
  • 2001
3 Excerpts

Fr901469

  • A. Fujie, H. Muramatsu, S. Yoshimura, M. Hashimoto, N. Shigematsu, S. Takase
  • a novel antifungal antibiotic from an…
  • 2001

N

  • K. Masubuchi, T. Okada, +11 authors I. Horii
  • Shimma, Synthesis and antifungal activity of…
  • 2001

Similar Papers

Loading similar papers…