From molecules to cells: imaging soft samples with the atomic force microscope.

@article{Radmacher1992FromMT,
  title={From molecules to cells: imaging soft samples with the atomic force microscope.},
  author={Manfred Radmacher and R W Tillamnn and Monika Fritz and Hermann Eduard Gaub},
  journal={Science},
  year={1992},
  volume={257 5078},
  pages={1900-5}
}
Since its invention a few years ago, the atomic force microscope has become one of the most widely used near-field microscopes. Surfaces of hard sample are imaged routinely with atomic resolution. Soft samples, however, remain challenging. An overview is presented on the application of atomic force microscopy to organic samples ranging from thin ordered films at molecular resolution to living cells. Fundamental mechanisms of the image formation are discussed, and novel imaging modes are… CONTINUE READING