From migraine genes to mechanisms.

  title={From migraine genes to mechanisms.},
  author={Else Tolner and Thijs Houben and Gisela M. Terwindt and Boukje de Vries and Michel D. Ferrari and Arn M. J. M. van den Maagdenberg},
  volume={156 Suppl 1},
Migraine is a common multifactorial episodic brain disorder with strong genetic basis. Monogenic subtypes include rare familial hemiplegic migraine, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, familial advanced sleep-phase syndrome (FASPS), and retinal vasculopathy with cerebral leukodystrophy. Functional studies of disease-causing mutations in cellular and/or transgenic models revealed enhanced (glutamatergic) neurotransmission and abnormal… CONTINUE READING
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