From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis.

@article{Ehninger2009FromMT,
  title={From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis.},
  author={Dan Ehninger and Petrus J de Vries and Alcino J. Silva},
  journal={Journal of intellectual disability research : JIDR},
  year={2009},
  volume={53 10},
  pages={838-51}
}
BACKGROUND Tuberous sclerosis (TSC) is a multi-system disorder caused by heterozygous mutations in the TSC1 or TSC2 gene and is often associated with neuropsychiatric symptoms, including intellectual disability, specific neuropsychological deficits, autism, other behavioural disorders and epilepsy. METHOD Here, we review evidence from animal models of TSC for the role of specific molecular and cellular processes in the pathogenesis of cognitive, developmental and epilepsy-related… CONTINUE READING
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