From low arterial- to low tissue-oxygenation strategy. An evolutionary theory.

@article{Massabuau2001FromLA,
  title={From low arterial- to low tissue-oxygenation strategy. An evolutionary theory.},
  author={J. C. Massabuau},
  journal={Respiration physiology},
  year={2001},
  volume={128 3},
  pages={249-61}
}
The primitive atmosphere where aerobic life started on earth was hypoxic and hypercapnic. Remarkably, an adaptation strategy whereby O(2) partial pressure, P(O(2)), in the arterial blood is maintained within a low and narrow range of 1-3 kPa, largely independent of inspired P(O(2)), has also been reported in modern water-breathers. In mammalian tissues, including brain, the most frequently measured P(O(2)) is in the same low range. Based on the postulate that basic cellular machinery has been… CONTINUE READING

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