From local structure to a global framework: recognition of protein folds

  title={From local structure to a global framework: recognition of protein folds},
  author={Agnel Praveen Joseph and Alexandre G. de Brevern},
  journal={Journal of The Royal Society Interface},
Protein folding has been a major area of research for many years. Nonetheless, the mechanisms leading to the formation of an active biological fold are still not fully apprehended. The huge amount of available sequence and structural information provides hints to identify the putative fold for a given sequence. Indeed, protein structures prefer a limited number of local backbone conformations, some being characterized by preferences for certain amino acids. These preferences largely depend on… 

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