From ketones, aldehydes or alkyl halides to terminal 1,1-difluoroolefins using BrF3

@inproceedings{Hagooly2005FromKA,
  title={From ketones, aldehydes or alkyl halides to terminal 1,1-difluoroolefins using BrF3},
  author={Aviv Hagooly and Shlomo Rozen},
  year={2005}
}
Abstract Terminal difluoromethylenes were prepared by two different routes: (a) by treating ketones and aldehydes with bis(methylthio)methane, producing 2-alkyl-1,1-bis(methylthio)alkene ( 2 ) (b) reacting alkyl halides with tris(methylthio)methane forming 1-alkyl-1,1,1-tris(methylthio)alkane derivatives ( 7 ). The reaction of either 2 or 7 with BrF 3 , followed by oxidation with HOF·CH 3 CN gave the difluorosulfonyl derivatives 4 . Consecutive treatment with Zn led to the target… CONTINUE READING