From isolated GH deficiency to multiple pituitary hormone deficiency: an evolving continuum - a KIMS analysis.

@article{Klose2009FromIG,
  title={From isolated GH deficiency to multiple pituitary hormone deficiency: an evolving continuum - a KIMS analysis.},
  author={Marianne C Klose and Bj{\"o}rn G. Jonsson and Roger Abs and Vera M. Popovi{\'c} and Maria Koltowska-H{\"a}ggstr{\"o}m and Bernhard Saller and Ulla Feldt-Rasmussen and Ione A. Kourides},
  journal={European journal of endocrinology},
  year={2009},
  volume={161 Suppl 1},
  pages={
          S75-83
        }
}
OBJECTIVE To describe baseline clinical presentation, treatment effects and evolution of isolated GH deficiency (IGHD) to multiple pituitary hormone deficiency (MPHD) in adult-onset (AO) GHD. DESIGN Observational prospective study. METHODS Baseline characteristics were recorded in 4110 patients with organic AO-GHD, who were GH naïve prior to entry into the Pfizer International Metabolic Database (KIMS; 283 (7%) IGHD, 3827 MPHD). The effect of GH replacement after 2 years was assessed in… CONTINUE READING

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