From ion channels to complex networks: magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy.


Medical management and drug development for epilepsy emphasizes increasing pharmacological specificity to improve efficacy while minimizing side effects. However, growing evidence supports potential benefits of "magic shotgun" over "magic bullet" approaches to treatment of complex disease processes. We discuss experimental and theoretical evidence… (More)
DOI: 10.1016/j.mehy.2008.09.049