From innate immunity to de-novo designed antimicrobial peptides.

  title={From innate immunity to de-novo designed antimicrobial peptides.},
  author={Yechiel Shai},
  journal={Current pharmaceutical design},
  volume={8 9},
Antimicrobial peptides are a large group of gene-encoded, net positively charged polypeptides, produced by living organisms of all types including human and plants. They are mobilized shortly after infection as part of the innate immunity of these species and act rapidly to neutralize a broad range of microbes. Nowadays, thousands of native and de-novo designed antimicrobial peptides are available. They vary considerably in length, composition, charge and secondary structure. Despite these… CONTINUE READING