From inflammation to sickness and depression: when the immune system subjugates the brain

@article{Dantzer2008FromIT,
  title={From inflammation to sickness and depression: when the immune system subjugates the brain},
  author={Robert Dantzer and Jason C. O'Connor and Gregory G Freund and Rodney W Johnson and Keith W. Kelley},
  journal={Nature Reviews Neuroscience},
  year={2008},
  volume={9},
  pages={46-56}
}
In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour. When activation of the peripheral immune system continues unabated, such as during systemic infections, cancer or autoimmune diseases, the ensuing immune signalling to the brain can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals. These phenomena might account for the increased prevalence of… CONTINUE READING
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