From individual proteins to proteomic samples: characterization of O-glycosylation sites in human chorionic gonadotropin and human-plasma proteins

@article{Bai2015FromIP,
  title={From individual proteins to proteomic samples: characterization of O-glycosylation sites in human chorionic gonadotropin and human-plasma proteins},
  author={Xue Bai and Daoyuan Li and Jing Zhu and Yudong Guan and Qunye Zhang and Lianli Chi},
  journal={Analytical and Bioanalytical Chemistry},
  year={2015},
  volume={407},
  pages={1857-1869}
}
O-glycosylation-site characterization of individual glycoproteins is a major challenge because of the heterogeneity of O-glycan core structures. In proteomic studies, O-glycosylation-site analysis is even more difficult because of the complexity of the sample. In this work, we designed a rapid and convenient workflow for characterizing the O-glycosylation sites of individual proteins and the human-plasma proteome. A mixture of exoglycosidases was used to partially remove O-glycan chains and… CONTINUE READING

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