From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment.

@article{Ramrez2010FromHP,
  title={From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment.},
  author={Julita Ram{\'i}rez and Kara R Lukin and James Hagman},
  journal={Current opinion in immunology},
  year={2010},
  volume={22 2},
  pages={177-84}
}
The generation of B lymphocytes from hematopoietic progenitors requires lineage-specific transcription factors that progressively direct cell fate choices. Differentiation of hematopoietic stem cells to lymphoid progenitors requires Ikaros-dependent lineage priming and graded levels of PU.1, which are controlled by Ikaros and Gfi1. E2A drives expression of EBF1, which initiates B lineage specification. EBF1, in addition to Pax5, is necessary for commitment to the B cell lineage. As a model of… CONTINUE READING