From haematopoietic stem cells to complex differentiation landscapes

@article{Laurenti2018FromHS,
  title={From haematopoietic stem cells to complex differentiation landscapes},
  author={Elisa Laurenti and Berthold G{\"o}ttgens},
  journal={Nature},
  year={2018},
  volume={553},
  pages={418-426}
}
The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state… CONTINUE READING
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