From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

@article{Rogers2016FromGD,
  title={From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways},
  author={G. Rogers and D. Keating and R. Young and M. Wong and J. Licinio and S. Wesselingh},
  journal={Molecular Psychiatry},
  year={2016},
  volume={21},
  pages={738 - 748}
}
The human body hosts an enormous abundance and diversity of microbes, which perform a range of essential and beneficial functions. Our appreciation of the importance of these microbial communities to many aspects of human physiology has grown dramatically in recent years. We know, for example, that animals raised in a germ-free environment exhibit substantially altered immune and metabolic function, while the disruption of commensal microbiota in humans is associated with the development of a… Expand
Current Perspectives on Gut Microbiome Dysbiosis and Depression
TLDR
This review focuses on recent studies investigating the relationship between gut microbiome dysbiosis and the pathogenesis of depression, and demonstrates encouraging results in the treatment of depression. Expand
The intriguing role of the Gut Microbiome in the etiology and pathogenesis of Neuropsychiatric Disorders
TLDR
The contribution of the gut microbes in the process of neurodevelopment is reviewed and light is shed on the etiology of many neuropsychological disorders from the perspective of gut dysbiotic states to provide novel therapeutic strategies against neuro-Psychological disorders. Expand
The role of the microbiota-gut-brain axis in neuropsychiatric disorders
TLDR
Evidence for the influence of gut microbiota on the brain and behavior in Alzheimer disease, dementia, anxiety, autism spectrum disorder, bipolar disorder, major depressive disorder, Parkinson’s disease, and schizophrenia is reviewed. Expand
Human Gut Microbiota and Mental Health: Advancements and Challenges in Microbe-Based Therapeutic Interventions
TLDR
An integrative and personalized approach, where combinations of microbe-based therapeutic interventions to modulate gut microbes and in-use psychological treatment practices can be integrated and based on patient’s gut microbiome can be potentially adopted for effective treatment of the mental disorders is proposed. Expand
“I Am I and My Bacterial Circumstances”: Linking Gut Microbiome, Neurodevelopment, and Depression
TLDR
The role played by the gut microbiome in neurodevelopment and in the etiology of the depressive syndrome is explored, including nutritional, immunological, and energy homeostasis approaches. Expand
The Transformative Possibilities of the Microbiota and Mycobiota for Health, Disease, Aging, and Technological Innovation
TLDR
The mycobiota and microbiota–gut–brain axis offer new research horizons and represents a great potential target for new therapeutics, including approaches based around inflammatory disruptive process, genetically engineered drug delivery systems, diseased cell culling “kill switches”, phage-like therapies, medicinal chemistry, or microbial parabiosis. Expand
The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain
TLDR
The following review examines the evidence surrounding the gut microbiota in behavior and psychiatric illness, the role of the microbiota in schizophrenia and the potential for antipsychotics to alter the gut microbiome and promote adverse metabolic events. Expand
Editorial: The Promise of Psychiatric Translational Research: Exploring How the Gut Can Influence Brain Development.
  • E. Szigethy
  • Medicine
  • Journal of the American Academy of Child and Adolescent Psychiatry
  • 2019
TLDR
This study is the first longitudinal study to evaluate whether repeated episodes of gastroenteritis during early childhood predicts behavioral problems in later childhood and mental illness during adolescence and has an exploratory mechanistic objective: whether systemic inflammation in later Childhood and adolescence moderates this brain-gut relationship. Expand
Gut-brain axis: A matter of concern in neuropsychiatric disorders…!
The gut microbiota is composed of a large number of microbes, usually regarded as commensal bacteria. It has become gradually clear that gastrointestinal microbiota affects gut pathophysiology andExpand
Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions
TLDR
This review summarizes the recent findings supporting the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders and highlights the recent advances in improving of neurological diseases by probiotics/prebiotics/synbiotics and fecal microbiota transplantation via the concept of the Gut–brain axis. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 307 REFERENCES
The impact of microbiota on brain and behavior: mechanisms & therapeutic potential.
TLDR
The concept of a microbiome-brain-gut axis is emerging, suggesting microbiota-modulating strategies may be a tractable therapeutic approach for developing novel treatments for CNS disorders. Expand
The microbiome‐gut‐brain axis: from bowel to behavior
  • J. Cryan, S. O'Mahony
  • Biology, Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2011
TLDR
It is shown that germ‐free mice display alterations in stress‐responsivity, central neurochemistry and behavior indicative of a reduction in anxiety in comparison to conventional mice, offering the enticing proposition that specific modulation of the enteric microbiota may be a useful strategy for stress‐related disorders and for modulating the co‐morbid aspects of gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease. Expand
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
TLDR
The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders. Expand
Melancholic microbes: a link between gut microbiota and depression?
  • T. Dinan, J. Cryan
  • Biology, Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2013
TLDR
Evidence is demonstrated that there is a distinct perturbation of the composition of gut microbiota in animal models of depression and chronic stress, which has direct implications for the development of psychobiotic‐based therapeutic strategies for psychiatric disorders. Expand
Effects of gut microbiota on the brain: implications for psychiatry.
TLDR
This commentary provides a brief overview of research related to gut‐brain communication in a context that allows neuroscientists and psychiatrists to take note and consider the role of microbiota in their researchrelated to CNS function and behaviour. Expand
Brain–Gut–Microbe Communication in Health and Disease
TLDR
The evidence supporting a role for the enteric flora in brain–gut axis disorders is explored with the spotlight on the clinical relevance for irritable bowel syndrome, a stress-related functional gastrointestinal disorder. Expand
The Gut-Brain Axis: The Missing Link in Depression
  • Alper Evrensel, M. Ceylan
  • Medicine
  • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2015
TLDR
The latest literature examining the effects of the gut microbiota on depression is presented, including preclinical research in rodents suggested that certain probiotics have antidepressant and anxiolytic activities. Expand
The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease.
TLDR
Gaining a better understanding of the relationship between behavior and the microbiota could provide insight into the pathogenesis of functional and inflammatory bowel disorders. Expand
Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism
TLDR
It is demonstrated that dysbiosis of the gut microbiome may have a causal role in the development of depressive-like behaviors, in a pathway that is mediated through the host’s metabolism. Expand
Effect of intestinal microbial ecology on the developing brain.
TLDR
A brief review of the intestinal microbiome is provided, with a focus on new studies showing that there is an important link between the microbes that inhabit the intestinal tract and the developing brain. Expand
...
1
2
3
4
5
...