From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

  title={From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways},
  author={Geraint B. Rogers and D J Keating and Richard L Young and M L Wong and Julio Licinio and Steven L. Wesselingh},
  journal={Molecular Psychiatry},
  pages={738 - 748}
The human body hosts an enormous abundance and diversity of microbes, which perform a range of essential and beneficial functions. Our appreciation of the importance of these microbial communities to many aspects of human physiology has grown dramatically in recent years. We know, for example, that animals raised in a germ-free environment exhibit substantially altered immune and metabolic function, while the disruption of commensal microbiota in humans is associated with the development of a… 

Current Perspectives on Gut Microbiome Dysbiosis and Depression

This review focuses on recent studies investigating the relationship between gut microbiome dysbiosis and the pathogenesis of depression, and demonstrates encouraging results in the treatment of depression.

The intriguing role of the Gut Microbiome in the etiology and pathogenesis of Neuropsychiatric Disorders

The contribution of the gut microbes in the process of neurodevelopment is reviewed and light is shed on the etiology of many neuropsychological disorders from the perspective of gut dysbiotic states to provide novel therapeutic strategies against neuro-Psychological disorders.

The role of the microbiota-gut-brain axis in neuropsychiatric disorders

Evidence for the influence of gut microbiota on the brain and behavior in Alzheimer disease, dementia, anxiety, autism spectrum disorder, bipolar disorder, major depressive disorder, Parkinson’s disease, and schizophrenia is reviewed.

Human Gut Microbiota and Mental Health: Advancements and Challenges in Microbe-Based Therapeutic Interventions

An integrative and personalized approach, where combinations of microbe-based therapeutic interventions to modulate gut microbes and in-use psychological treatment practices can be integrated and based on patient’s gut microbiome can be potentially adopted for effective treatment of the mental disorders is proposed.

“I Am I and My Bacterial Circumstances”: Linking Gut Microbiome, Neurodevelopment, and Depression

The role played by the gut microbiome in neurodevelopment and in the etiology of the depressive syndrome is explored, including nutritional, immunological, and energy homeostasis approaches.

Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut–Brain Axis

How various environmental pollutants such as phthalates, heavy metals, Bisphenol A and particulate matter may alter the intricate microbiota–gut–brain axis thereby impacting the authors' neurological and overall mental health is discussed.

The Transformative Possibilities of the Microbiota and Mycobiota for Health, Disease, Aging, and Technological Innovation

The mycobiota and microbiota–gut–brain axis offer new research horizons and represents a great potential target for new therapeutics, including approaches based around inflammatory disruptive process, genetically engineered drug delivery systems, diseased cell culling “kill switches”, phage-like therapies, medicinal chemistry, or microbial parabiosis.

Gut-brain axis: A matter of concern in neuropsychiatric disorders…!

The gut microbiota is composed of a large number of microbes, usually regarded as commensal bacteria. It has become gradually clear that gastrointestinal microbiota affects gut pathophysiology and

The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain

The following review examines the evidence surrounding the gut microbiota in behavior and psychiatric illness, the role of the microbiota in schizophrenia and the potential for antipsychotics to alter the gut microbiome and promote adverse metabolic events.

Editorial: The Promise of Psychiatric Translational Research: Exploring How the Gut Can Influence Brain Development.

  • E. Szigethy
  • Psychology, Medicine
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 2019



The impact of microbiota on brain and behavior: mechanisms & therapeutic potential.

The concept of a microbiome-brain-gut axis is emerging, suggesting microbiota-modulating strategies may be a tractable therapeutic approach for developing novel treatments for CNS disorders.

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.

The microbiome‐gut‐brain axis: from bowel to behavior

  • J. CryanS. O'Mahony
  • Biology, Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2011
It is shown that germ‐free mice display alterations in stress‐responsivity, central neurochemistry and behavior indicative of a reduction in anxiety in comparison to conventional mice, offering the enticing proposition that specific modulation of the enteric microbiota may be a useful strategy for stress‐related disorders and for modulating the co‐morbid aspects of gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease.

Melancholic microbes: a link between gut microbiota and depression?

  • T. DinanJ. Cryan
  • Biology, Psychology
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2013
Evidence is demonstrated that there is a distinct perturbation of the composition of gut microbiota in animal models of depression and chronic stress, which has direct implications for the development of psychobiotic‐based therapeutic strategies for psychiatric disorders.

Effects of gut microbiota on the brain: implications for psychiatry.

This commentary provides a brief overview of research related to gut‐brain communication in a context that allows neuroscientists and psychiatrists to take note and consider the role of microbiota in their researchrelated to CNS function and behaviour.

Brain–Gut–Microbe Communication in Health and Disease

The evidence supporting a role for the enteric flora in brain–gut axis disorders is explored with the spotlight on the clinical relevance for irritable bowel syndrome, a stress-related functional gastrointestinal disorder.

The Gut-Brain Axis: The Missing Link in Depression

  • Alper EvrenselM. Ceylan
  • Psychology, Biology
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2015
The latest literature examining the effects of the gut microbiota on depression is presented, including preclinical research in rodents suggested that certain probiotics have antidepressant and anxiolytic activities.

The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease.

Gaining a better understanding of the relationship between behavior and the microbiota could provide insight into the pathogenesis of functional and inflammatory bowel disorders.

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

It is demonstrated that dysbiosis of the gut microbiome may have a causal role in the development of depressive-like behaviors, in a pathway that is mediated through the host’s metabolism.