From ghrelin to ghrelin's O-acyl transferase.

  title={From ghrelin to ghrelin's O-acyl transferase.},
  author={Jesus Aguirre Guti{\'e}rrez and Jill A Willency and Michael D. Knierman and Tamer Coskun and Patricia J. Solenberg and Doug R Perkins and Richard E. Higgs and John E. S. Hale},
  journal={Methods in enzymology},
The hormone ghrelin is a unique signaling peptide with powerful metabolic effects, mediated by its acylated forms. The acyl modification of ghrelin is unique in that it takes place via a susceptible ester linkage in the conserved serine-3 of ghrelin and is composed principally of octanoyl and, to lesser extent, decanoyl fatty acids. The nature of this ester linkage makes it susceptible to esterases, which convert it to its des-acyl forms, and, if not adequately inhibited, the conversion to des… CONTINUE READING
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