From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity.

  title={From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity.},
  author={Yunfei Wang and Margaret R. Spitz and Yong Zhu and Qiong Dong and Sanjay Shete and X ianchao Wu},
  journal={DNA repair},
  volume={2 8},
This study correlated the extent of induced in vitro chromosomal damage, assessed by the mutagen sensitivity assay, with genotypes of the X-ray repair cross complementing group 1 (XRCC1) gene, which encodes for a base excision repair protein. There are two common polymorphisms that cause amino acid substitutions in XRCC1, one at codon 194 in exon 6 and another at codon 399 in exon 10. We genotyped these two polymorphisms in 524 healthy subjects and performed mutagen sensitivity assays using… CONTINUE READING


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