From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma.

@article{Dunn2013FromGT,
  title={From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma.},
  author={Gavin P Dunn and Ovidiu C. Andronesi and Daniel P Cahill},
  journal={Neurosurgical focus},
  year={2013},
  volume={34 2},
  pages={E2}
}
The characterization of the genomic alterations across all human cancers is changing the way that malignant disease is defined and treated. This paradigm is extending to glioma, where the discovery of recurrent mutations in the isocitrate dehydrogenase 1 (IDH1) gene has shed new light on the molecular landscape in glioma and other IDH-mutant cancers. The IDH1 mutations are present in the vast majority of low-grade gliomas and secondary glioblastomas. Rapidly emerging work on the consequences of… CONTINUE READING
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