From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.

@article{Goedert2001FromGT,
  title={From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.},
  author={Michel Goedert and Maria Grazia Spillantini and Louise C. Serpell and John Berriman and Michael J. Smith and Ross Jakes and R. A. Crowther},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2001},
  volume={356 1406},
  pages={213-27}
}
The most common degenerative diseases of the human brain are characterized by the presence of abnormal filamentous inclusions in affected nerve cells and glial cells. These diseases can be grouped into two classes, based on the identity of the major proteinaceous components of the filamentous assemblies. The filaments are made of either the microtubule-associated protein tau or the protein alpha-synuclein. Importantly, the discovery of mutations in the tau gene in familial forms of… CONTINUE READING

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