From funny current to HCN channels: 20 years of excitation.

  title={From funny current to HCN channels: 20 years of excitation.},
  author={Eric A. Accili and Catherine Proenza and Mirko Baruscotti and Dario DiFrancesco},
  journal={News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society},
The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K(+) and Na(+), modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties. 
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