From fundamental studies of sporulation to applied spore research.

  title={From fundamental studies of sporulation to applied spore research.},
  author={Imrich Bar{\'a}k and Ezio Ricca and Simon M Cutting},
  journal={Molecular microbiology},
  volume={55 2},
Sporulation in the Gram-positive bacterium, Bacillus subtilis, has been used as an excellent model system to study cell differentiation for almost half a century. This research has given us a detailed picture of the genetic, physiological and biochemical mechanisms that allow bacteria to survive harsh environmental conditions by forming highly robust spores. Although many basic aspects of this process are now understood in great detail, including the crystal and NMR structures of some of the… CONTINUE READING

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