From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration

@inproceedings{Ausoni2009FromFT,
  title={From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration},
  author={Simonetta Ausoni and Saverio Sartore},
  booktitle={The Journal of cell biology},
  year={2009}
}
Different vertebrate species have different cardiac regeneration rates: high in teleost fish, moderate in urodele amphibians, and almost negligible in mammals. Regeneration may occur through stem and progenitor cell differentiation or via dedifferentiation with residual cardiomyocytes reentering the cell cycle. In this review, we will examine the ability of zebrafish and newts to respond to cardiac damage with de novo cardiogenesis, whereas rodents and humans respond with a marked fibrogenic… CONTINUE READING

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