From fear to safety and back: reversal of fear in the human brain.

@article{Schiller2008FromFT,
  title={From fear to safety and back: reversal of fear in the human brain.},
  author={Daniela Schiller and Ifat Levy and Yael Niv and Joseph E. LeDoux and Elizabeth A. Phelps},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 45},
  pages={
          11517-25
        }
}
Fear learning is a rapid and persistent process that promotes defense against threats and reduces the need to relearn about danger. However, it is also important to flexibly readjust fear behavior when circumstances change. Indeed, a failure to adjust to changing conditions may contribute to anxiety disorders. A central, yet neglected aspect of fear modulation is the ability to flexibly shift fear responses from one stimulus to another if a once-threatening stimulus becomes safe or a once-safe… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 236 CITATIONS, ESTIMATED 64% COVERAGE

The neural correlates of negative prediction error signaling in human fear conditioning

VIEW 8 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Clarifying the neural substrates of threat and safety reversal learning in humans

VIEW 11 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Neural basis of impaired safety signaling in Obsessive Compulsive Disorder.

VIEW 9 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

Triggering Avoidance: Dissociable Influences of Aversive Pavlovian Conditioned Stimuli on Human Instrumental Behavior

VIEW 3 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Neural signals of vicarious extinction learning 1 2

VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Safety encoding in the basal amygdala.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Effects of rapid eye movement sleep deprivation on fear extinction recall and prediction error signaling.

VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 20 Highly Influenced Citations

  • Averaged 19 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 69 REFERENCES

Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Reinforcement learning signals in the human striatum distinguish learners from nonlearners during reward-based decision making.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Splitting the difference: how does the brain code reward episodes?

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Temporal difference models describe higher-order learning in humans

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Dissociating valence of outcome from behavioral control in human orbital and ventral prefrontal cortices.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Lesions of nucleus accumbens disrupt learning about aversive outcomes.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL