From fatty liver to fibrosis: a tale of "second hit".

  title={From fatty liver to fibrosis: a tale of "second hit".},
  author={Metin Başaranoğlu and G{\"o}kçen Başaranoğlu and Hakan Şent{\"u}rk},
  journal={World journal of gastroenterology},
  volume={19 8},
Although much is known about how fat accumulates in the liver, much remains unknown about how this causes sustained hepatocellular injury. The consequences of injury are recognized as nonalcoholic steatohepatitis (NASH) and progressive fibrosis. The accumulation of fat within the hepatocytes sensitizes the liver to injury from a variety of causes and the regenerative capacity of a fatty liver is impaired. An additional stressor is sometimes referred to as a "second hit" in a paradigm that… CONTINUE READING
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