From endolysins to Artilysin®s: novel enzyme-based approaches to kill drug-resistant bacteria.

Abstract

One of the last untapped reservoirs in nature for the identification of new anti-microbials is bacteriophages, the natural killers of bacteria. Lytic bacteriophages encode peptidoglycan (PG) lytic enzymes able to degrade the PG layer in different steps of their infection cycle. Endolysins degrade the bacterial cell wall at the end of the infection cycle… (More)
DOI: 10.1042/BST20150192

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