From endocannabinoid profiling to 'endocannabinoid therapeutics'.

  title={From endocannabinoid profiling to 'endocannabinoid therapeutics'.},
  author={Alessia Ligresti and Stefania Petrosino and Vincenzo Di Marzo},
  journal={Current opinion in chemical biology},
  volume={13 3},
The discovery of the endocannabinoid signalling system, that is, of cannabinoid receptors, their endogenous ligands, known as endocannabinoids, and of endocannabinoid anabolic and catabolic enzymes, raised several questions regarding the physiopathological role of these mediators. Several of these questions were answered by investigating alterations in the levels of the most studied endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), in tissues of animal models of disorders… CONTINUE READING