From dopamine to salience to psychosis—linking biology, pharmacology and phenomenology of psychosis

  title={From dopamine to salience to psychosis—linking biology, pharmacology and phenomenology of psychosis},
  author={S. Kapur and R. Mizrahi and M. Li},
  journal={Schizophrenia Research},
  • S. Kapur, R. Mizrahi, M. Li
  • Published 2005
  • Psychology, Medicine
  • Schizophrenia Research
  • How does an excess in a neurochemical lead someone to being paranoid about the intentions of their neighbour? And why does blocking a dopamine receptor improve this symptom? In this article we present a heuristic framework which attempts to link the biology, phenomenology and pharmacology of psychosis. Focussing on dopamine's role in reward prediction and motivational salience we propose that psychosis arises from an aberrant assignment of novelty and salience to objects and associations… CONTINUE READING
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