From dopamine to salience to psychosis—linking biology, pharmacology and phenomenology of psychosis

@article{Kapur2005FromDT,
  title={From dopamine to salience to psychosis—linking biology, pharmacology and phenomenology of psychosis},
  author={Shitij Kapur and Romina Mizrahi and Ming Li},
  journal={Schizophrenia Research},
  year={2005},
  volume={79},
  pages={59-68}
}
View on Elsevier
doi.org
466 Citations
Highly Influential Citations
26
Background Citations
201
Methods Citations
7
Results Citations
10

466 Citations

Citation Type

Citation Type

Does the dopamine hypothesis explain schizophrenia?
TLDR
It is argued that the current model of aberrant salience explains psychosis in schizophrenia and provides a plausible linkage between the pharmacological and cognitive aspects of the disease.
From prediction error to psychosis: ketamine as a pharmacological model of delusions
TLDR
It is suggested that ketamine may provide an appropriate model to investigate the formative stages of symptom evolution in schizophrenia, and thereby provide a window into the earliest and otherwise inaccessible aspects of the disease process.
Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines
Salience and dysregulation of the dopaminergic system
Salience and dysregulation of the dopaminergic system.
Functional neuroimaging of pathophysiological mesolimbic dopamine system and aberrant motivational salience in schizophrenia
TLDR
Overall, the increased bottom-up activation of the vStr may result from an intensified recruitment of this region during exaggerated assignment of salience to the conditioned rewards irrespective of the context, and the finding of disturbed cortico-striatal functional interaction in schizophrenic patients is in line with the dysconnection hypothesis of schizophrenia.
From the prodrome to chronic schizophrenia: the neurobiology underlying psychotic symptoms and cognitive impairments.
TLDR
Evidence links greater dopamine synthesis capacity to poorer cognitive performance and altered frontal cortical function measured using functional imaging during cognitive tasks, and the nature of other neurofunctional alterations in the disorder, in particular in the serotonergic system and neuroinflammation is reviewed.
The enduring centrality of dopamine in the pathophysiology of schizophrenia: in vivo evidence from the prodrome to the first psychotic episode.
A disturbed sense of self in the psychosis prodrome: Linking phenomenology and neurobiology
The dopamine hypothesis of schizophrenia: version III--the final common pathway.
TLDR
The dopamine hypothesis of schizophrenia-version III is synthesized into a comprehensive framework that links risk factors, including pregnancy and obstetric complications, stress and trauma, drug use, and genes, to increased presynaptic striatal dopaminergic function.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 65 REFERENCES
How antipsychotics become anti-"psychotic"--from dopamine to salience to psychosis.
  • S. Kapur
  • Psychology, Medicine
    Trends in pharmacological sciences
  • 2004
Hyperactivity of Associations in Psychosis
  • R. Miller
  • Psychology, Medicine
    The Australian and New Zealand journal of psychiatry
  • 1989
TLDR
This essay has dealt exclusively with the positive (productive) symptoms of psychosis, and their treatment, and briefly traced the origin of the idea that hyperactive associations of thought (i.e. of inductive inference) play an important part in the psychology of acute psychosis.
Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.
  • S. Kapur
  • Psychology, Medicine
    The American journal of psychiatry
  • 2003
TLDR
A heuristic framework for linking the psychological and biological in psychosis is provided and it is proposed that a dysregulated, hyperdopaminergic state, at a "brain" level of description and analysis, leads to an aberrant assignment of salience to the elements of one's experience, at an "mind" level.
The time course of neuroleptic therapy for psychosis: role of learning processes and implications for concepts of psychotic illness
TLDR
It is suggested that the pharmacological characteristics of the hypothetical learning process involved in generating psychotic symptoms are analogous to those of a simpler learning process, defineable in animal experiments — namely, the reward component in instrumental conditioning.
Half a century of antipsychotics and still a central role for dopamine D2 receptors
  • S. Kapur, D. Mamo
  • Psychology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2003
Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis.
TLDR
It is predicted that the atypical antipsychotic effect can be produced by appropriate modulation of the D(2) receptor alone; the blockade of other receptors is neither necessary nor sufficient.
The Role of Serotonin in Schizophrenia and the Place of Serotonin‐Dopamine Antagonist Antipsychotics
  • H. Meltzer
  • Psychology, Medicine
    Journal of clinical psychopharmacology
  • 1995
TLDR
The serotonin‐dopamine antagonists may prove to have many other uses in psychiatry beyond schizophrenia because of their low propensity to cause extrapyramidal symptoms and their pharmacologic mechanism of action may be more complex than only strong 5‐HT2A and weak D2 block.
How antipsychotics work: The patients' perspective
Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.
TLDR
Elevated synaptic dopamine was predictive of good treatment response of positive symptoms to antipsychotic drugs and increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons.
The involvement of nucleus accumbens dopamine in appetitive and aversive motivation
  • J. Salamone
  • Psychology, Biology
    Behavioural Brain Research
  • 1994
...
1
2
3
4
5
...