From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat.

Abstract

The development of drug taking from controlled intake to drug addiction was studied by means of an animal model. Outbred rats had continuous free access to water and drinking fluids containing different concentrations of a drug for 7-9 months. After an abstinence period of 4-9 months, the drug was offered again (retest). Previous ethological classification… (More)

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@article{Wolffgramm1995FromCD, title={From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat.}, author={Jochen Wolffgramm and Andrea Heyne}, journal={Behavioural brain research}, year={1995}, volume={70 1}, pages={77-94} }