From concept to reality: the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer.

@article{Dussault2009FromCT,
  title={From concept to reality: the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer.},
  author={Isabelle Dussault and Steven F. Bellon},
  journal={Anti-cancer agents in medicinal chemistry},
  year={2009},
  volume={9 2},
  pages={221-9}
}
c-Met and RON are receptor tyrosine kinases (RTK) that are closely related, both from a homology as well as from a functional stand point. Both receptors can induce cell migration, invasion, proliferation and survival in response to their respective ligand. Moreover, both possess oncogenic activity in vitro, in animal models in vivo and are often deregulated in human cancers. c-Met attracted a lot of interest shortly after its discovery in the mid-1980s because of its unusual role in cell… CONTINUE READING
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