From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer.

@article{Fabris2014FromCA,
  title={From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer.},
  author={Victoria T Fabris},
  journal={Cancer genetics},
  year={2014},
  volume={207 6},
  pages={
          233-46
        }
}
Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 74 references