From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development

@inproceedings{Svennerholm2011FromCT,
  title={From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development},
  author={A M Svennerholm},
  booktitle={The Indian journal of medical research},
  year={2011}
}
It was shown earlier that immune responses against cholera toxin (CT) as well as Vibrio cholerae lipopolysaccharide (LPS) or whole bacterial cells (WC) were protective and that these different antibody specificities co-operated synergistically for protection against experimental cholera. Similarly, antibodies against the heat-labile toxin (LT) and major colonization factors (CFs) of enterotoxingenic Escherichia coli (ETEC) co-operated synergistically for protection against LT-producing ETEC… CONTINUE READING