From bench to drug: human seizure modeling using Drosophila.

  title={From bench to drug: human seizure modeling using Drosophila.},
  author={Juan Song and Mark A. Tanouye},
  journal={Progress in neurobiology},
  volume={84 2},
Studies of human seizure disorders have revealed that susceptibility to seizures is greatly influenced by genetic factors. In addition to causing epilepsy, genetic factors can suppress seizures and epileptogenesis. Examination of seizure-suppressor genes is challenging in humans. However, such genes are readily identified and analyzed in a Drosophila animal model of epilepsy. In this article, the epilepsy phenotype of Drosophila seizure-sensitive mutants is reviewed. A novel class of genes… CONTINUE READING

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