From bench to bedside and back again: translational research in autoinflammation

@article{Holzinger2015FromBT,
  title={From bench to bedside and back again: translational research in autoinflammation},
  author={Dirk Holzinger and Christoph Kessel and Alessia Omenetti and Marco Gattorno},
  journal={Nature Reviews Rheumatology},
  year={2015},
  volume={11},
  pages={573-585}
}
Translational research approaches brought major changes to the understanding and treatment options of autoinflammatory diseases. Patients with common complex multifactorial diseases such as systemic-onset juvenile idiopathic arthritis (sJIA), and particularly those with rare monogenic autoinflammatory diseases such as cryopyrin-associated periodic syndromes (CAPS) or TNF receptor-associated periodic syndrome (TRAPS), benefited from a deeper understanding of the pathophysiological mechanisms and… CONTINUE READING
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