From bench to bedside and back?

  title={From bench to bedside and back?},
  author={Diane Gershon},
US academic health centres face challenges that may threaten the future vitality of the clinical research enterprise, but they are fighting back, says Diane Gershon. 
Risk of venous thromboembolism in patients with celiac disease: A systematic review and meta‐analysis
This meta‐analysis conducted with the aims to better characterize this possible association between chronic inflammation and vitamin deficiency and venous thromboembolism in patients with celiac disease.
Anesthesia Medications and Interaction with Chemotherapeutic Agents
Correctly paired anesthetic procedures and medications will reduce perioperative inflammatory and immune changes that could potentially contribute to improved results for future cancer patients.
Current globalization of drug interventional clinical trials: characteristics and associated factors, 2011–2013
The globalization of clinical trials in the emerging regions of Asia, South Africa, and Eastern Europe developed in parallel with the factors of economic drive, population for recruitment, and regulatory constraints.
Finance offers intellectual challenges and economic rewards
More and more scientists are finding stimulation, fulfillment, and pecuniary rewards in the financial sector.
Systems biology and combination therapy in the quest for clinical efficacy
This perspective focuses on opportunities and challenges inherent in the application of mathematical modeling and systems approaches to pharmacology, specifically with respect to the idea of achieving combinatorial selectivity through use of multicomponent drugs.
Inflammatory Mediator Profiles Differ in Sepsis Patients With and Without Bacteremia
Systemic levels of cytokines are altered during infection and sepsis. This prospective observational study aimed to investigate whether plasma levels of multiple inflammatory mediators differed
Precision Medicine in Lymphoma by Innovative Instrumental Platforms
Concerns and difficulties for the adoption of genetic testing in routine are still present, as well as affordability, reliability and the poor confidence of some patients for these tests, however, genetic testing based on predictive markers may offers many advantages to caregivers and patients and their introduction in clinical routine is justified.
High Compliance with Scheduled Nimodipine Is Associated with Better Outcome in Aneurysmal Subarachnoid Hemorrhage Patients Cotreated with Heparin Infusion
In aneurysmal subarachnoid hemorrhage patients with modified Fisher scores 2 through 4 who are cotreated with a low-dose heparin infusion, full compliance with nimodipine dosing was associated with increased odds of discharge to home.
Combining Lovastatin and Minocycline for the Treatment of Fragile X Syndrome: Results From the LovaMiX Clinical Trial
The combination of lovastatin and minocycline is safe in patients for FXS individuals and appears to improve several elements of the behavior, setting the stage for a larger, placebo-controlled double-blind clinical trial to confirm the beneficial effects of the combined therapy.
Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms
Preliminary work in endothelial cells has shown that transient episodes of hyperglycemia can induce changes in gene expression that are dependent on modifications to histone tails (for example, methylation), and that these changes persist after return to normoglycemia.