From behavior to development: genes for sexual behavior define the neuronal sexual switch in Drosophila

  title={From behavior to development: genes for sexual behavior define the neuronal sexual switch in Drosophila},
  author={Daisuke Yamamoto and Kazuko Fujitani and Kazue Usui and Hiroki Ito and Yoshiro Nakano},
  journal={Mechanisms of Development},

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Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating

It is suggested that sensory inputs mediated and/or processed by the tarsal receptors, suboesophageal ganglion, antennal lobe and mushroom body contribute to the regulation of male–female courtship.

Male-Specific Expression of the Fruitless Protein is not Common to all Drosophila Species

Male Drosophila melanogaster mutants for the fruitless (fru) locus exhibit enhanced male-to-male courtship and malformation of the male-specific muscle of Lawrence (MOL) is induced by male motoneurons innervating it.

Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression

It is shown here that the Fru protein is not detected in the female central nervous system (CNS), despite the similar level of expression of fru mRNA in both male and female CNS.

A gene necessary for normal male courtship, yellow, acts downstream of fruitless in the Drosophila melanogaster larval brain.

It is demonstrated that the yellow (y) gene is genetically downstream of fru in the 3(rd)-instar larval brain and suggested that y is a downstream member of the fru branch of the D. melanogaster sex determination hierarchy, where it plays a currently unknown role in the development of adult male wing extension during courtship.


Results indicate that sexually dimorphic expression of the Fru protein has been subjected to species-specific modulation during evolution.

Aberrant splicing and altered spatial expression patterns in fruitless mutants of Drosophila melanogaster.

It is suggested that the mutant phenotypes in fru(2, fru(3), fru(4), and fru(sat) animals are due to a failure to appropriately splice P1 transcripts, whereas the mutant phenotype of fru(1) animals is due to the reduction or absence of P1 Transcripts within specific regions of the CNS.

Sex in flies: what 'body--mind' dichotomy?

A cis-regulatory Sequence Within the yellow Locus of Drosophila melanogaster Required for Normal Male Mating Success

Visualization of gene action via GFP and a Yellow antibody suggests that the MRS directs y transcription in a small number of cells in the third instar CNS, the developmental stage previously implicated in the role of y with regard to male courtship behavior.



Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster.

  • J. BeloteB. S. Baker
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1987
The results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.

Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain.

It is suggested that fru functions downstream of tra in the sex-determination cascade in some neural cells and that inappropriate sexual development of these cells in the fru mutants results in altered sexual orientation of the fly.

Commitment of abdominal neuroblasts in Drosophila to a male or female fate is dependent on genes of the sex-determining hierarchy.

From the analysis of intersexes generated by dominant alleles of dsx, it has been concluded that the same neuroblasts provide the sex-specific neuroblast in both male and female central nervous systems.

Behavioral and neurobiological implications of sex-determining factors in Drosophila.

Results obtained from assessments of doublesex mutations' effects on general reproductive actions and on a particular component of the courtship sequence (male "singing" behavior) lead to the suggestion that there is a previously unrecognized branch within the sex-determination hierarchy, which controls the differentiation of the male- and female- specific phenotypes of Drosophila.

Genetic feminization of brain structures and changed sexual orientation in male Drosophila

The neural basis of sexual orientation in Drosophila was studied by the production of males with regionally feminized brains, which facilitated the creation of lines with a stable pattern of feminization.

Control of male reproductive behavior by the central nervous system of Drosophila: dissection of a courtship pathway by genetic mosaics.

In gynandromorphs of Drosophila, a detailed examination was made of the association between male courtship behavior and the chromosomal genotype of various parts of the central nervous system. Mosaic

Differentiation of a male-specific muscle in Drosophila melanogaster does not require the sex-determining genes doublesex or intersex.

There is no role for the genes doublesex or intersex in either the generation of the male-specific muscles in males or their suppression in females.