From behavior to development: genes for sexual behavior define the neuronal sexual switch in Drosophila

@article{Yamamoto1998FromBT,
  title={From behavior to development: genes for sexual behavior define the neuronal sexual switch in Drosophila},
  author={Daisuke Yamamoto and Kazuko Fujitani and Kazue Usui and Hiroki Ito and Yoshiro Nakano},
  journal={Mechanisms of Development},
  year={1998},
  volume={73},
  pages={135-146}
}

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TLDR
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References

SHOWING 1-10 OF 131 REFERENCES

Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster.

  • J. BeloteB. S. Baker
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1987
TLDR
The results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.

Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain.

TLDR
It is suggested that fru functions downstream of tra in the sex-determination cascade in some neural cells and that inappropriate sexual development of these cells in the fru mutants results in altered sexual orientation of the fly.

Commitment of abdominal neuroblasts in Drosophila to a male or female fate is dependent on genes of the sex-determining hierarchy.

TLDR
From the analysis of intersexes generated by dominant alleles of dsx, it has been concluded that the same neuroblasts provide the sex-specific neuroblast in both male and female central nervous systems.

Behavioral and neurobiological implications of sex-determining factors in Drosophila.

TLDR
Results obtained from assessments of doublesex mutations' effects on general reproductive actions and on a particular component of the courtship sequence (male "singing" behavior) lead to the suggestion that there is a previously unrecognized branch within the sex-determination hierarchy, which controls the differentiation of the male- and female- specific phenotypes of Drosophila.

Genetic feminization of brain structures and changed sexual orientation in male Drosophila

TLDR
The neural basis of sexual orientation in Drosophila was studied by the production of males with regionally feminized brains, which facilitated the creation of lines with a stable pattern of feminization.

Control of male reproductive behavior by the central nervous system of Drosophila: dissection of a courtship pathway by genetic mosaics.

In gynandromorphs of Drosophila, a detailed examination was made of the association between male courtship behavior and the chromosomal genotype of various parts of the central nervous system. Mosaic

Differentiation of a male-specific muscle in Drosophila melanogaster does not require the sex-determining genes doublesex or intersex.

TLDR
There is no role for the genes doublesex or intersex in either the generation of the male-specific muscles in males or their suppression in females.
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