From basics to clinical: A comprehensive review on spinal cord injury

@article{Silva2014FromBT,
  title={From basics to clinical: A comprehensive review on spinal cord injury},
  author={Nuno A. Silva and Nuno Sousa and Rui L Reis and Ant{\'o}nio Jos{\'e} Salgado},
  journal={Progress in Neurobiology},
  year={2014},
  volume={114},
  pages={25-57}
}

Pathophysiology and Therapeutic Approaches for Spinal Cord Injury

This work presents a detailed description of the physiology and anatomy of the spinal cord and the pathophysiology of SCI, and provides an overview of different molecular strategies that demonstrate promising potential in the modulation of the secondary injury events that promote neuroprotection or neuroregeneration.

Current Status of Spinal Cord Regenerative Therapies: A Review

This review discusses the present status of various cell-based therapies, which are being used for treating SCI, and the stem cell–based therapy has been proposed as a promising treatment strategy for SCI.

Stem Cells Therapy for Spinal Cord Injury: An Overview of Clinical Trials

An overview of clinical trials, recorded in clinical trial.gov during 2005–2019, aimed to evaluate the use of stem cell-based therapy in SCI, show the safety and efficacy of stemcell therapy in patients with SCI.

Regenerative medicine for spinal cord injury: focus on stem cells and biomaterials

This review digs into the possibility of cell treatment to improve medical chances in SCI repair, discussing the development of biomaterials aiming to promote in situ cell delivery.

Regenerative treatment of spinal cord injury. Literature review. Part 2

This review highlights SCI epidemiological and pathogenetic problems, existing therapy, as well as promising methods of regenerative therapy, which are very promising to effectively treat SCI.

Recent Advances in the Regenerative Approaches for Traumatic Spinal Cord Injury: Materials Perspective.

The regenerative approach using nanofibrous scaffolds is discussed with a focus on their fabrication methods and their properties that define their functionality performed to heal the neural tissue efficiently.

Application of developmental principles for spinal cord repair after injury.

Current advances in stem cell technology are highlighted in terms of refinement and precise design of the appropriate stem cell population to be transplanted not only for cell replacement but also for modulation of the host environment.

Neuroregenerative-Rehabilitative Therapy for Spinal Cord Injury

Different types of cells available, routes of administration available to transplant these cells, dosages of cell and optimum time after injury at which cells should be transplanted based on world-wide literature are discussed.
...

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