From association to causality: the new frontier for complex traits

  title={From association to causality: the new frontier for complex traits},
  author={Nicholas Katsanis},
  booktitle={Genome Medicine},
Technological and analytical advances have led to an unprecedented catalog of genomic regions associated with a broad range of clinically relevant phenotypes in humans. However, some examples notwithstanding, the causes of the overwhelming majority of genetic diseases remain obscure. More importantly, an emerging lesson from genome-wide association studies is that, in most instances, the resolution necessary for identifying actual genes that underlie the phenotype is limited, as is our ability… CONTINUE READING

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