From antibody insult to fibrosis in neonatal lupus - the heart of the matter

@article{Buyon2003FromAI,
  title={From antibody insult to fibrosis in neonatal lupus - the heart of the matter},
  author={Jill P Buyon and Robert Michael Clancy},
  journal={Arthritis Research & Therapy},
  year={2003},
  volume={5},
  pages={266 - 270}
}
Few diseases exemplify the integration of research from bench to bedside as well as neonatal lupus, often referred to as a model of passively acquired autoimmunity. In essence, this disease encompasses two patients, both the mother and her child. The signature histologic lesion of autoimmune-associated congenital heart block is fibrosis of the conducting tissue, and in some cases the surrounding myocardium. It is astounding how rapid and, in most cases, irreversible is the fibrotic response to… CONTINUE READING
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