From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia.

@article{Chen2011FromAO,
  title={From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia.},
  author={Sai-juan Chen and Guang-Biao Zhou and Xiao-Wei Zhang and J Mao and Hugues de Th{\'e} and Zhu Chen},
  journal={Blood},
  year={2011},
  volume={117 24},
  pages={6425-37}
}
Arsenic had been used in treating malignancies from the 18th to mid-20th century. In the past 3 decades, arsenic was revived and shown to be able to induce complete remission and to achieve, when combined with all-trans retinoic acid and chemotherapy, a 5-year overall survival of 90% in patients with acute promyelocytic leukemia driven by the t(15;17) translocation-generated promyelocytic leukemia-retinoic acid receptor α (PML-RARα) fusion. Molecularly, arsenic binds thiol residues and induces… CONTINUE READING