From altered synaptic plasticity to atypical learning: A computational model of Down syndrome.


Learning and memory rely on the adaptation of synaptic connections. Research on the neurophysiology of Down syndrome has characterized an atypical pattern of synaptic plasticity with limited long-term potentiation (LTP) and increased long-term depression (LTD). Here we present a neurocomputational model that instantiates this LTP/LTD imbalance to explore… (More)
DOI: 10.1016/j.cognition.2017.10.021


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