From alcohols to indoles: a tandem Ru catalyzed hydrogen-transfer Fischer indole synthesis.

Abstract

In a new version of the Fischer indole synthesis, primary and secondary alcohols have been catalytically oxidized in the presence of phenylhydrazines and protic or Lewis acids to give the corresponding indoles. The overall reaction can be accomplished in one step, and the use of alcohols instead of aldehyes or ketones as starting materials has several… (More)
DOI: 10.1021/ol3030956

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